TNF and Sepsis: Monocytes from patients with sepsis, who are known to be in the state of endotoxin tolerance, produce less pro‐inflammatory cytokines, such as tumor necrosis factor‐alpha (TNF‐α), interleukin (IL)‐12, IL‐23, and IL‐6, in response to LPS stimulation, compared to monocytes from healthy volunteers.11