SOCS3 and psoriasis: In summary, we found that etanercept could alleviate the symptoms of psoriasis of IMQ‐induced mice, and the underlying mechanism was to inhibit the JAK/STAT3 signaling pathway and enhance the expression of SOCS1 and SOCS3, thereby decreasing the expression of inflammatory cytokines, reducing Th17/Treg ratio and promoting the polarization of macrophages to M2.