Furthermore, the upregulation of SPTBN1 reduced Bcl2 content but ascended the contents of Bax and cleaved caspase3 compared with the Ov‐NC group, suggesting the promoting impacts of SPTBN1 overexpression on RA‐FLSs apoptosis (Figure 3I). The gene discussed is SPTBN1; the disease is rheumatoid arthritis.