Elsewhere, SPTBN1 overexpression reduced the contents of MMP2, MMP9, IL‐8, IL‐1β, IL‐6, and Bcl2 but ascended the levels of Bax and cleaved caspase3 in RA‐FLSs, implying that SPTBN1 upregulation helped to repress the migration, inflammation and promoted the apoptosis of RA. The gene discussed is CXCL8; the disease is rheumatoid arthritis.