Pandharipande et al reported that one‐time MRI screening (sensitivity 56%, specificity 97% for pancreatic cyst and early stage cancer) in 50‐year‐old individuals with a 2.4 to 4.5 RR for PC (eg, BRCA2) led to a negligible gain in LE of 3.9 to 5.8 days per simulated individual. The gene discussed is BRCA2; the disease is cancer.