In clinical applications, FLCN deficiency is associated with Birt-Hogg-Dubé syndrome and may additionally contribute to abnormal lymph nodes.16,54 These findings may lead to improved understanding of the effects of FLCN-related diseases on lymphatics, which may translate to novel therapeutic approaches to lymphatic disorders. The gene discussed is FLCN; the disease is Birt-Hogg-Dube syndrome.