In a multivariable logistic regression analysis, in model 1 analyzed with clinical and anatomical parameters, acute coronary syndrome (odds ratio [OR]: 2.54; 95% CI: 1.01-6.39; P = 0.047), male gender (OR: 0.28; 95% CI: 0.09-0.84; P = 0.024), and use of angiotensin-converting enzyme inhibitor or angiotensin II receptor blockers (OR: 0.27; 95% CI: 0.09-0.76; P = 0.013) are independent correlates of decreased FFR during 12 months. This evidence concerns the gene ACE and acute coronary syndrome.