IL27 and infection: At the site of infection, S. aureus B(t) is able to induce a local immunosuppressive microenvironment that suppresses T cells to promote its persistence (term cTB(t)T(t)) via various immune evasion strategies for instance, through the induction of interleukins IL-10 and IL-27, or S. aureus enterotoxins, which promote the expansion and functions of MDSCs leading to T-cell suppression.4