MET and colorectal cancer: Debernardi et al. found that the long interspersed nuclear elements 1, located in the second intron of MET oncogene (LINE1-MET), hypomethylation is an important feature of early-onset colorectal cancer (CRC), that LINE1-MET hypomethylation in colorectal adenomas is associated with a high risk of developing colorectal cancer, and that LINE1-MET methylation levels are of great significance for prognostic assessment of patients after surgical resection of polyps [104].