MAP1LC3A and metabolic dysfunction-associated steatotic liver disease: However, the circLDLR OE + PA/OA group had an obvious lower accumulation of GFP- and RFP-LC3 than the circLDLR OE group (P < 0.05, P < 0.01), which demonstrated that OA/PA pretreatment also had a certain inhibitory effect on autophagy flux, but the role of circLDLR and autophagy on NAFLD is still unclear.