At present, the well-studied brain reaction autoantibodies associated with SLE include anti-N-methyl-d-aspartate receptors (NMDAR), anti-ribosome P0, microtubule associated protein 2 (MAP-2), matrix metalloproteinase 9 (MMP-9), RO anti body [58], and anti U1RNP and anti-phospholipid (APL) antibodies [59–61]. The gene discussed is MMP9; the disease is systemic lupus erythematosus.