A functional role for the hypermethylation and gene silencing of PCDHαβγ family genes (PCDHAC2, PCDHB7, PCDHB15, PCDHGA1 and PCDHGA6) was also identified recently in colorectal cancer influencing the WNT/B-catenin pathway implicated in proliferation, survival and migration [56]. The gene discussed is PCDHGA1; the disease is colorectal cancer.