Nevertheless, the obtained data parallel what has been observed in breast cancer cell lines, in which overexpression of other members of the PCDH-β gene family (PCDHB4 and PCDHB19) inhibited anchorage-independent cell growth in soft agar, colony formation ability and in vivo tumor growth in NOD/SCID mice [53]. The gene discussed is PCDHB4; the disease is breast carcinoma.