In WM115 and WM266-4 cells which are derived, respectively, from the primary tumor and the cutaneous metastasis of the same patient, PCDHB15 showed differential methylation above 40% in at least two CpGs positions located at + 566 and + 610 pb from the TSS, respectively (Fig. 1A). The gene discussed is PCDHB15; the disease is neoplasm.