To address this possibility, we examined the DNA methylation levels of the hypomethylated and hypermethylated CpGs of severe COVID-19 and sepsis patients in monocytes isolated from healthy donor PBMCs that had been treated in vitro with inflammatory cytokines like IFNα, IFNγ, and TNFα [26] (accession number GSE134425). The gene discussed is TNF; the disease is Sepsis.