We have previously shown that higher levels of circulating ETP identified a subpopulation of type 2 diabetes patients that responded to insulin sensitizing treatment [34] and that ETP in both serum and urine was independently associated with adverse outcomes in both CKD with mixed etiology [35], in patients with type 1 diabetes [20], and type 2 diabetes [21]. The gene discussed is INS; the disease is type 1 diabetes mellitus.