As SMG1 is the first factor to initiate NMD activation and showed a high-predicted value of tumor survival and inflammation (Fig. 1) we generated SMG1KD-derived cells from 4T1 breast cancer, Panc02 for Pancreatic Adenocarcinoma and B16/F10 as Melanoma murine models. This evidence concerns the gene SMG1 and breast carcinoma.