To isolate the effect of the immune response against a specific antigen and interrogate the mechanisms of immune escape mediated by NMD, we performed the experiment in immunodeficient mice (Rag2/IL2rg-/-) that were adoptively transferred with activated OT-I lymphocytes post tumor implantation and quantified for their luciferase signal along the course of the experiment (Fig. 5C-G). This evidence concerns the gene RAG2 and neoplasm.