Mice were implanted with both tumors (Panco02.SMG1KD and Panc02.gCtrl) expressing similar levels of luciferase and SIINFEKL (Fig. 6D, S7C) and treated with anti-PD-1 and anti-CTLA-4 at days 1, 4 and 7 post tumor inoculation (Fig. 6C). Here, CTLA4 is linked to neoplasm.