CEACAM5 and cancer: We confirmed the prognostic value of several pre-documented biomarkers including age [24], clinicopathological stage [25], lymphatic invasion [26], levels of circulating CEA [27], fibrinogen [28], bilirubin [29], and CRP [30] (Figure S4A); however, blood inflammation-derived biomarkers such as NLR [31], lymphocyte-to-monocyte ratio [32], prognostic nutrition index [33], and platelet-to-lymphocyte ratio [34] did not correlate with the cancer progression (Figure S4B).