In addition to circRNAs and miRNAs, ras-related C3 botulinum toxin substrate 1 (RAC1) is commonly found in mammal tissues and cells, functioning as an epithelial differentiation pleiotropic regulator and involved in apoptosis-related pathways through the production of reactive oxygen species [25]. RAC1 has been implicated in multiple cellular processes, such as cell proliferation, tumor metastasis, and epithelial-mesenchymal transition [26]. Here, RAC1 is linked to neoplasm.