Interestingly, the aggregated (mean of all probes) Pearson's correlation (Pearson's correlation coefficient = -0.44, p = 6.6e-14 for COAD) conveyed that HAND2 significantly downregulated in CRC (288 colon cancer) and has a reverse correlation with the methylation status of CpG islands (Supplementary Fig. 1). This evidence concerns the gene HAND2 and colorectal carcinoma.