At 14 dpc, some differentially expressed genes are involved in response infections, such as transcriptional regulator ATRX-like (ATRX, logFC = 6.4), which plays a role in the maintenance of herpes simplex virus heterochromatin [17, 18]; the viral heterochromatin is formed during the lytic infection, where nucleosomes are assembled on the viral DNA and act as a epigenetic barrier to viral gene expression [19–21]. The gene discussed is ATRX; the disease is infection.