Interestingly, we extracted mitochondrial and cytosolic proteins from lung tissue and found that AEC-specific citratemt accumulation increased the protein and phosphorylation level of mitochondrial DRP1 in vivo (Fig. 6f, g), which suggested that the increase in DRP1 in the lungs of ALI mice was associated with mitochondria. Here, DNM1L is linked to acute respiratory distress syndrome.