ALK and non-small cell lung carcinoma: Ceritinib (CERI), also called LDK378, is a tyrosine kinase inhibitor of anaplastic lymphoma kinase (ALK) approved by the Food and Drug Administration (FDA) in 2014.(Shaw et al. 2014) It shows impressive activity in ALK-rearranged non-small-cell lung cancer and is simultaneously inhibited by downregulating the signal effector YB1 (Crunkhorn 2017).