The factors including male sex, SBP, grade of hypertension, ɑ1-MG, mAlb, HCY, BUN, UA, Scr, RBP, GLU, SOD, drinking history and eGFR that were statistically significant (P < 0.05) in the t-test were used as the independent variable, whereas the early renal damage occurred was taken as the dependent variable, establishing a univariate logistic regression model, which showed that the grade of hypertension, SBP, Hcy, Scr, RBP, mAlb, UA, Lpa were risk factors for HM, SOD, drinking history and eGFR were protective factors (Fig. 1). This evidence concerns the gene RBP4 and Hypertension.