GHRL and colorectal carcinoma: Some studies have shown that an EE not only influences the brain structure and function37 but also significantly inhibits tumor growth in colon cancer5 .A previous study on EE intervention for 8 weeks in rats with CRC also showed that an EE could increase brain-gut peptide expression (especially ghrelin secretion) and enhance intestinal mucosal immunological functions, thus ameliorating intestinal dysfunction and maintaining the integrity of the intestinal mucosal barrier.