In line with this observation, downregulation of HNF1B via lentivirus-mediated short hairpin RNA (shRNA) greatly attenuated cell proliferation and migration in the PCa V16A cell line while ectopic expression of HNF1B elevated cellular proliferation of RWPE1 cells (Fig. 1d–f and Supplementary Fig. 1j). The gene discussed is HNF1B; the disease is posterior cortical atrophy.