GEMIN4 and posterior cortical atrophy: To further verify if rs2955626, rs684232 and rs461251 are directly involved in the regulation of VPS53, FAM57A and GEMIN4, we applied the CRISPR/Cas9 genome editing approach in PCa cell line V16A and obtained four independent mixed cell clones with partial depletion of each SNP enhancer region at 17p13.3.