Among these functionally uncharacterized PCa risk loci, the 17q12/HNF1B locus with several independent SNPs has been reproducibly found in association with PCa susceptibility14–21, and interestingly the phenome-wide association analysis (PheWAS) using FinnGen cohort data (n = 176,899) observed a specific top-ranked association of the 17q12/HNF1B locus variants with PCa across 2,264 disease endpoints (Fig. 1c). Here, HNF1B is linked to posterior cortical atrophy.