Given that the 17q12/HNF1B has been reported as a cross-cancer pleiotropic genetic risk locus14–26, our work revealed an understanding of its underlying causation and biological mechanisms implicating in PCa risk prediction and prognosis, while exhibited as an example for the comprehensive evaluation of this locus contributing to risk association and disease progression in other types of cancers. The gene discussed is HNF1B; the disease is posterior cortical atrophy.