Lastly, we observe that common binding sites for HNF1B and TMPRSS2-ERG can explain more of genetic effects on PCa predisposition than that of their unique binding sites, and present a solid example of HNF1B co-option of TMPRSS2-ERG co-regulating the 17p13.3 PCa risk locus. This evidence concerns the gene TMPRSS2 and posterior cortical atrophy.