To investigate potential functional categories of HNF1B knockdown target genes, we performed gene set enrichment analysis (GSEA) and revealed several cell cycle relevant terms highly enriched in HNF1B upregulated genes (Fig. 4c, d), further supporting the above described role of HNF1B in promoting PCa cell proliferation and invasion (Fig. 1d–f and Supplementary Fig. 1b–j). This evidence concerns the gene HNF1B and posterior cortical atrophy.