HNF1B and posterior cortical atrophy: To test the biological relevance of HNF1B in PCa, we performed a cell proliferation assay and found that several PCa cell lines including LNCaP, VCaP, DU145, and PC3 harboring siRNAs against HNF1B displayed reduced cell growth compared to cells harboring control siRNA (Supplementary Fig. 1b–i).