Furthermore, through querying multiple clinical PCa datasets, we found a positive expression correlation between FAM57A and ERG or HNF1B in prostate tumors (Fig. 6j, k), but not in adjacent normal prostate tissues (Supplementary Fig. 10e, f), indicating ERG and HNF1B directed transcriptional reprogramming in human PCa tumorigenesis. This evidence concerns the gene TLCD3A and posterior cortical atrophy.