HNF1B and posterior cortical atrophy: We next performed CRISPR/Cas9-mediated genome editing in the PCa cell lines 22Rv1 and V16A to delete each of the 13 SNP-containing regions and observed great downregulation of HNF1B in most of mixed clones with knockout (KO) of individual SNP-region (Fig. 2c and Supplementary Fig. 2p).