This analysis revealed that transcription factor genes are indeed preferentially to be enriched in PCa risk loci (P = 2.49 × 10−6, hypergeometric distribution test; Fig. 1a), including many with poorly characterized causal roles (Fig. 1b), except for HOXB13, RFX6, and NKX3-1 that have been shown to be causally linked to PCa susceptibility and tumourigenesis46–49. The gene discussed is RFX6; the disease is posterior cortical atrophy.