We next examined an enhancer-like function of the 17p13.3 region harboring the SNPs rs2955626, rs684232 and rs461251 for PCa susceptibility genes VPS53, FAM57A and GEMIN4. Hence, we proceeded to test whether these SNPs could directly alter the promoter activity of VPS53, FAM57A and GEMIN4, respectively. The gene discussed is GEMIN4; the disease is posterior cortical atrophy.