To validate the effect of the HNF1B cell cycle signature among a set of clinical variables to patient prognosis, we conducted multivariate analysis by incorporating clinical variables including age, Gleason score, PSA, tumor stage, ERG-fusion status, seminal vesical status and extraprostatic extension status in PCa patients using both the continuous and categorical HNF1B cell cycle signature by the median stratification. This evidence concerns the gene HNF1B and posterior cortical atrophy.