In this study, we revealed an extensive germline-somatic interaction implicating PCa susceptibility and progression through the oncogenic regulatory circuits, consisting of the most frequent PCa-specific somatic genomic alteration TMPRSS2-ERG, and several germline PCa risk locus genes such as HNF1B at 17q12 and VPS53-FAM57A-GEMIN4 at 17p13.3 (Fig. 7k). Here, HNF1B is linked to posterior cortical atrophy.