TMPRSS2 and posterior cortical atrophy: Given that a cluster of cis-regulatory elements were reported to regulate elevated expression of TMPRSS2-ERG79 and that TMPRSS2-ERG and HNF1B co-bound at a broad H3K27ac-marked super-enhancer region in HNF1B (Fig. 3d) and at the rs684232/17p13.3 region (Fig. 6f), we investigated whether known transcription inhibitors could perturb this transcriptional misregulation circuit that drives the expression of several PCa risk-associated genes.