We therefore focus on the 17q12/HNF1B locus and seek to identify functional causal variants of this region as well as investigate role of HNF1B in PCa progression and predisposition to aggressive disease, which in turn may be an example for functional study of this cross-cancer pleiotropic genetic association in other types of cancers. The gene discussed is HNF1B; the disease is posterior cortical atrophy.