Remarkably, depletion of the Lats1 tumor suppressor (Lats1-CKO) increased the fraction of basal-like cells at the expense of mature luminal cells in vitro (Fig. 1a, right panel, and Fig S1d), in concordance with our earlier observation that Lats1-CKO mammary tumors are enriched for basal-like features61. Here, LATS1 is linked to breast cancer.