Elucidating distinct functions of LATS1 and LATS2 might help resolve these apparent discrepancies; for instance, we previously reported that depletion of LATS1 but not LATS2 in the mouse MMTV-PyMT model, which shares features with human lumB breast cancer, results in the adoption of more basal-like characteristics and increased resistance to tamoxifen61. Here, LATS2 is linked to breast cancer.