To test the necessity of YAP/TAZ in LATS1/2-deleted tumor development, we introduced Yap-floxed and Taz/Wwtr1-floxed alleles41 in our Lats1/2f/f; lsl-EYFP; K8CreERT2 model (Lats1/2f/f; YAPf/f; TAZf/f; lsl-EYFP; K8CreERT2), allowing us to conditionally co-delete YAP and TAZ together with LATS1 and LATS2. Here, LATS2 is linked to neoplasm.