Sox9-positive (Sox9+) cells in LATS1/2-deleted carcinomas were also ERα-negative (ER−) (Supplementary Fig. 2a), and when profiling Lats1/2f/f; lsl-EYFP; K8CreERT2 mice at earlier time points (1–6 days after the last Tamoxifen dose), we observed that Sox9+ cells proliferated and gradually acquired K14 expression in this model (Supplementary Fig. 2b). This evidence concerns the gene ESR1 and carcinoma.