We performed an immunohistochemical validation of this marker combination (Fig. 3C) and observed strong staining of KRT18 in all cases of the NEC-like IDH2 and NEC-like SMARCA4/ARID1A class, variable staining intensity in the ACC class and no staining in all investigated olfactory neuroblastomas and most squamous cell carcinomas (Fig. 3D). This evidence concerns the gene IDH2 and neuroendocrine carcinoma.