IL2 and infection: A perturbation of this balance via either sustained regulatory (e.g. iLD-IL-2 immunotherapy) or inflammatory (e.g. infection) environment can alter the composition of the soluble mediators contained in the extracellular matrix, and consequently affect the interaction between the immune system and the local environment, leading to the remodelling of their transcriptional profile and an alteration of their threshold for further stimulation.