With normal aging in mice, the levels of S396 phosphorylation of Tau, a hallmark of AD, were increased in the cerebral cortex and hippocampus, while this did not occur to such an extent in the 18 M CpGfapcKO mice, where the level was nearly equal to that in the 6 M control group (Fig. 7T-V). This evidence concerns the gene MAPT and Alzheimer disease.