Intrigued by the potential upregulation of the CD47-SIRPα axis during early phases of CRC tumourigenesis, we investigated the protein expression of CD47 and SIRPα in the eight pT1 samples (online supplemental figure 10A) and 18 independent pT1 CRC tissues (figure 6A, B). This evidence concerns the gene SIRPA and colorectal carcinoma.