SIRPA and carcinoma: Similarly, SIRPα, or signal regulatory protein alpha, expression is mainly reported in myeloid cells36 which is in line with the observed increase in deconvoluted macrophages during tumour progression (figure 5A) and, interestingly, the expression of its binding partner on tumour cells, CD47, was increased in the epithelial compartment in dysplastic and carcinoma tissues (figure 5D).