PPARA and colorectal carcinoma: A decreased enrichment of genes associated with oxidative phosphorylation and concurrent increase in enrichment score of the glycolysis pathway, points toward a metabolic switch to aerobic glycolysis.23 24 Similarly, pathways in C4 decreased during CRC onset, which mainly consisted of pathways related to lipid metabolism, including Fatty Acid Omega Oxidation and peroxisome proliferator-activated receptor (PPAR) signalling.