CD8A and neoplasm: Furthermore, such prodrug nanoparticles could cause DNA damage to activate the STING pathway and stimulate a powerful immune response, which could then induce the maturation of DCs and tumor infiltration of CD8+ T cells in tumors, resulting in the elicitation of antitumor immunity in vivo and finally transforming “immune cold tumors” into “immune hot tumors” for combined chemotherapy and cancer immunotherapy.