xCT‐specific knockout in macrophages effectively limits tumorigenesis and metastasis in mice HCC models by reducing TAM recruitment and infiltration, inhibiting M2‐type polarization, and facilitating ferroptosis activity within TAMs, in which SOCS3‐STAT6‐PPAR‐γ signaling may be a crucial regulating pathway. This evidence concerns the gene SLC7A11 and hepatocellular carcinoma.