CD274 and neoplasm: Previous studies have shown that PD‐L1 can be expressed by TAMs, and its expression is related to the immunosuppressive activity of TAMs, which induces tumor immune escape.[53] We unveiled that xCT‐mediated macrophage ferroptosis significantly promoted the expression of PD‐L1, and xCT specific knockout in macrophages combined with anti‐PD‐L1 treatment acquire more substantial antitumor efficacy than xCT knockout in macrophages or anti‐PD‐L1 treatment alone.