Since TAM infiltration and the protumoral phenotype are known to carry out a crucial impact on inducing immune tolerance and interfering with effective immunotherapy,[34] and our previous finding revealed the close correlation between tumor cell ferroptosis with immune infiltration and to indicate the responsiveness of immunotherapy,[35] we further focused on whether xCT‐mediated macrophage ferroptosis and polarization regulated the efficacy of immunotherapy. Here, SLC7A11 is linked to neoplasm.