It was confirmed that the loss of SOCS3 made liver cells sensitive to tumor transformation.[48] SOCS3 is also an important regulatory factor associated with macrophage function, participating in the regulation of M1/M2 polarization.[49] Consistent with these findings, our study unveiled that xCT knockout in macrophages diminished the expression of phospho‐STAT6 and PPAR‐r and enhanced the expression of SOCS3, contributing to inhibition of M2 macrophage polarization. The gene discussed is SOCS3; the disease is neoplasm.