While no significant differences were observed in the numbers of tumor-infiltrating leukocytes (CD45+) and T cells (CD3+) between mock and STING ADC-treated mice (SI Appendix, Fig. S8 A and B), there was a significant decrease of CD4 T cells and an increase of CD8 T cells in their percentages of total T cells (CD3+) in tumors in response to the ADC treatment (Fig. 5 A and B and SI Appendix, Fig. S8C). Here, CD4 is linked to neoplasm.