TGFB1 and Friedreich ataxia: Although, we cannot rule out that HR is upregulated when HSCs enter the cell cycle, thereby resulting in repair of double strand breaks, as previously shown [29, 30], to confirm that TGFβ pathway inhibition creates an HR-competent state, our group has previously used pharmacological inhibitors that interfere with both HR (RAD51 foci formation by B02 inhibitor) and the TGFβ pathway (1D11) in FA cells.