PTK7 and breast cancer: This included genes such as PTK7, a transforming gene and prognostic marker for breast cancer and nodal metastasis involvement [45] (fold change relative to control in WT HOTAIR = 2.6, p = 0.008; in A783U HOTAIR = −1.4, p = 0.002); CDH11, a mesenchymal cadherin that is up-regulated in invasive breast cancer cell lines [46] (fold change in WT HOTAIR = 2.0, p = 0.01; in A783U HOTAIR = −1.6, p = 0.02); and GRIN2A, an oncogenic glutamate receptor (fold change in WT HOTAIR = 2.5, p = 0.006; in A783U HOTAIR = −3.7, p = 9.3 × 10−5).