YTHDC1 and cancer: Interestingly, using UALCAN (a tool for analyzing cancer OMICS data) to determine gene expression in normal breast tissue versus breast tumor specimens [40], there appears to be a lack of concordance in the relationship between YTHDC1 mRNA and protein levels in clinical samples: Average YTHDC1 mRNA levels were decreased across a breast tumor panel, while average protein levels were increased (S5C and S5D Fig).