There is grade 3 evidence for the use of angiogenesis inhibitors as salvage systemic therapy in vHL and/or sporadic hemangioblastomas, for instance interferon-beta [16], VEGF-targeting tyrosine kinase inhibitors such as sunitinib [17] and semaxanib [18] and monoclonal antibodies such as bevacixumab [19]. The gene discussed is IFNB1; the disease is hemangioblastoma.