VEGFA and hemangioblastoma: Analyzing levels of VEGF in CSF could possibly resolve this issue, and would probably be a superior method, but due to invasiveness and the predisposition of hemangioblastomas for the posterior fossa, lumbar puncture and CSF sampling is not a viable strategy for the disease, due to the inherent risks of lumbar puncture in patients with cerebellar and/or brainstem lesions [23].