A significant reduction in FN1 protein level was also achieved by miR-302d in both ICC staining and Western blot (p < 0.0001 compared with "TGFB1 + mock" group, p = 0.0085 compared with "TGFB1 + NC" group, Fig 8). The gene discussed is TGFB1; the disease is intrahepatic cholangiocarcinoma.