Univariate Cox regression analysis for death at 2 years performed for these factors revealed IPI score ≥3 vs. <3 (hazard ratio [HR] 11.3, 95% CI 1.4–90.5, P = 0.002), HGBL vs. DLBCL histology (HR 5.0, 95% CI 1.3–18.6, P = 0.02), double hit lymphoma vs. not (HR 8.0, 95% CI 1.8–36.0, P = 0.007) and CREBBP mutation vs. not (HR 2.8, 95% CI 0.76–10.5, P = 0.12). Here, CREBBP is linked to high grade B-cell lymphoma.