RCC2 and cancer: We further analyzed the expression levels of RCC2 among immune subtypes in pan-cancers and we found a significant correlation between RCC2 and C1 (wound healing), C2 (IFN-gamma dominant), C3 (inflammatory), C4 (lymphocyte depleted), C5 (immunologically), and C6 (TGF-b dominant) in ACC, UCEC, TGCT, STAD, SARC, THCA, LGG, MESO, PAAD, LUSC, LUAD, KIRP, BLCA, ESCA, HNSC, KICH and KIRC (p < 0.05, Supplementary Figure 6).