In the current research, we comprehensively profiled the expression and function of the RCC2 gene in pan-cancer through the public database, including TIMER, GEPIA2, UALCAN, cBioPortal, Kaplan-Meier plotter and TISIDB etc. We further evaluated the connection between RCC2 gene expression and immune microenvironment across various tumor types. The gene discussed is RCC2; the disease is cancer.