The aims of the present study (performed within the EFIGRO framework) were (1) to compare the effects of a family-based lifestyle and psychoeducation program (designed according to current pediatric guidelines14) and those of the same program plus supervised exercise training on VAT, ASAT, IMAAT, and PAT in children aged 8 to 12 years with overweight or obesity and (2) to explore the mediating effect of VAT reduction on insulin resistance. The gene discussed is INS; the disease is obesity disorder.