LEP and obesity due to melanocortin 4 receptor deficiency: Subcutaneous adipose tissue mRNA expressions of leptin and adiponectin were also unchanged following long-term (32 weeks) moderate-intensity exercise (cycling, running, or cross-training for 2 times/week at 65–70% maximal heart rate) at severe hypoxia (3500 m) in female and male individuals with obesity [126].