INS and obesity due to melanocortin 4 receptor deficiency: Similarly, 60 min of combined endurance (cycling at 50–90% of maximal aerobic power) and resistance training (50–70% of 1-RM, 4 × 6–15 repetitions) 3 times/week for 6 weeks with moderate hypoxia (~ 2800 m) reduced plasma insulin levels and improved glucose tolerance in adolescents with obesity, although there was no statistical significance between the hypoxic and normoxic conditions [138].