Mutations in the proline-rich transmembrane protein 2 (PRRT2) gene cause a broad and heterogeneous spectrum of neurological diseases sharing a paroxysmal nature, such as paroxysmal kinesigenic dyskinesia, episodic ataxia, benign familial infantile seizures, and hemiplegic migraine [1]. The gene discussed is PRRT2; the disease is familial or sporadic hemiplegic migraine.