In a recent follow-up study, van de Wetering et al. showed the dimeric form of PKM2 to play a crucial role in the pathogenesis of allergic airways disease by increasing signal transducer and activator of transcription 3 (STAT3)-dependent IL-1β–induced pro-inflammatory signaling in a mouse model of HDM-induced asthma (Fig. 2) [37]. Here, IL1B is linked to asthma.