In line with their findings from the mouse asthma model, GSTP levels were increased in the sputum of severe asthma patients, and sputum proteomics and transcriptomics also showed strong correlations between GSTP, PKM2, and glycolysis, pointing to a putative PKM2-GSTP-glycolysis signature associated with severe asthma [60]. The gene discussed is GSTP1; the disease is asthma.