In contrast, sTSLP reduced both inflammation of asthmatic airways (reduced airway hyperreactivity, Th2 cytokine production, and IgE production) and aerobic glycolysis in mice by decreasing lactate dehydrogenase A (LDHA) and lactic acid levels in bronchoalveolar lavage fluid (BALF), as well as HIF-1α- and LDHA-protein levels in airway epithelial cells of an asthma mouse model. The gene discussed is HIF1A; the disease is asthma.