SCARB2, also known as platelet glycoprotein 4, is a member of the CD36-like superfamily and is an important cell surface and skeletal muscle mitochondrial outer membrane glycoprotein involved in angiogenesis, thrombosis, atherosclerosis, malaria, diabetes, steatosis, dementia, and obesity [105]. The gene discussed is CD36; the disease is obesity due to melanocortin 4 receptor deficiency.