Recent studies have uncovered genomic variances in FLT4, CCN1, NOTCH4 (Delev et al., 2017; Scimone et al., 2020), ANRIL, CDKN2A/B, miR-18a (Florian et al., 2020), Smad6 (Fu et al., 2020), KLF4, SNAI1, and SNAI2 (Shoemaker et al., 2020), which may be associated with bAVM susceptibility. Here, NOTCH4 is linked to arteriovenous malformations of the brain.