Based on these mouse data, with an apparent opposite adipose tissue phenotype than observed in the family reported here, it could be hypothesized that the lipomatosis in this family is not the result of reduced folliculin expression, but due to a change in the expression of a specific gene target of PRDM10Cys677Tyr (Figs 3C and , 4D). The gene discussed is FLCN; the disease is lipomatosis.