In this study, we observed that the EAp53 classification system, which was analyzed according to a genotype–phenotype model via an evolutionary function evaluation,16 could effectively stratify TP53 missense mutations into high‐ and low = risk types and, for the first time, found the great prognostic value of this system in patients with advanced NSCLC. The gene discussed is TP53; the disease is non-small cell lung carcinoma.