For example, cytotoxic T lymphocyte antigen 4 (CTLA-4), PD-1, and PD-L1 are used ligand antagonists and other drugs interfere with immune checkpoints, which can directly stimulate the activation of cytotoxic T cells to initiate antitumor immunity and mediate sustained tumor suppression (Sadreddini et al., 2019). This evidence concerns the gene CD274 and neoplasm.