PTGS2 and major depressive disorder: Tao et al. (133) showed that luteolin containing PA methanolic extract mediates depression levels by balancing excitatory (glutamate) and inhibitory (GABA) brain monoamines, the voltage-gated ion channels (NaK/Ca-ATPase) and inhibition of NF-κB/TLR-4 pathway ameliorated neuroinflammation (TNF-α, IL-1β and COX-2) and improved seizure-complicated depression-like behavior in experimental epileptic mice.