Chronic administration of corticosterone (CORT) in rodents is used to mimic stress-related dysregulation of the HPA axis and is a well-recognized approach in depression modeling, and Kv et al. (77) administered corticosterone to mice to replicate a depression model in which the pathogenesis of depression is increased levels of pro-inflammatory cytokines such as COX-2, which promotes GC resistance due to an overactive HPA axis, thereby increasing susceptibility to inflammatory responses that further leading to the development of depression. Here, PTGS2 is linked to major depressive disorder.