Chronic administration of corticosterone (CORT) in rodents is used to mimic stress-related dysregulation of the HPA axis and is a well-recognized approach in depression modeling, and Kv et al. (77) administered corticosterone to mice to replicate a depression model in which the pathogenesis of depression is increased levels of pro-inflammatory cytokines such as COX-2, which promotes GC resistance due to an overactive HPA axis, thereby increasing susceptibility to inflammatory responses that further leading to the development of depression. The gene discussed is PTGS2; the disease is depressive disorder.