A 24-week randomized, double-blind, double-dummy, and multicentre clinical trial comparing Yishen Huazhuo decoction (YHD, a complex preparation from 7 herbs containing among many others the flavone icariin, the alkaloid tetramethylpyrazine and triterpenoid saponins, such as several astragalosides, which have been shown to decrease the level of amyloid-β in hippocampus and to improve the spatial learning and memory abilities in animal models) vs. the AChE inhibitor donepezil in Alzheimer’s disease patients indicates that YHD improves cognitive function vs. 5 mg/day donepezil. Here, ACHE is linked to Alzheimer disease.