Neprilysin degrades natriuretic peptides and vasodilators, which are negatively correlated with VSMC migration and proliferation, and the inhibition of neprilysin is related to the accumulation of Aβ peptides and the development of AD in adults with DS (Garg and Hassid, 1989; Miners et al., 2011; Karoor et al., 2013). This evidence concerns the gene MME and Alzheimer disease.